They seem like they'd be perfect for long rides. Comfortable seating position for a sporty bike and durable suspension make for a smooth ride. They do sit higher off the ground so gusts of wind coming and going from semi trucks might be tricky. Buell models such as the XB12Scg have a lower center of gravity which might be nice on the highway. One draw back is the comfortable riding position also makes for more wind resistance at higher speeds. I'd say go to the dealership and test drive a Ulysses on the highway.