Hey welcome to the forum! heres a must or people will flame you, pics or it didnt happen. Post something up.
My girl has a blast so im new to them as well, how many miles, what year, what kinda fluid you run in your primary, is it nee to you or have you had it a while?
A clutch adjustment and cable adjustment is a good place to start. Not to assume but sounds like your mechanical aptitude isnt all that great based on the questions youve asked.
If you have major transmission failure it cause cause the rear wheel to lock up, not to be mistaken or associated with the brake. Internal engine failure and seizing can translate to a wheel lock up as well.
The tuber guys would be the most helpful with transmission and primary internals i believe the blast shares more in common with the older buells vs the XBs.
Again welcome, try adjusting the clutch, the cable and even the primary chain can impact your ability to shift.