Depends on how far you are going.
In my opinion, if its anything under 500 miles and going through towns/cities, you don't need anything tools for the wheel axles besides the nut that comes in the under seat tool pouch. Chances are you'll be in a populated enough place you can either get a tow to or be near a shop to take the wheels off.
I usually take a set of standard wrenches, t25/27 bits, set of ratchet/socket allen keys, zip ties, bungee cords, 1 quart of oil, water, folded up shop towels, an extra bolt to go in my shifting linkage, extra spark plugs, a pair of dykes and maybe a few other odds and ends.
Obviously a much longer trip would require a bit more