What are you trying to do directly with ECMSpy and the WB? FYI. I would HIGHLY recommend donating for the latest version of ECMSpy.
Doesn't the PLX-SM have datalog capability? Or is it just a simple WB/gauge with an output?
Turn off closed loop in the Buell ECM. Datalog with your wideband, put your map and datalog file into MegaLog Viewer, the MLV algorithm will modify your map, install that map with ECMSpy and your USB cable, turn CL back on and enjoy the ride.